Table 3.

Multivariable-adjusted associations of adiposity measures and risk of overall heart failure among participants with euglycemia and prediabetes.

	Euglycemia				Prediabetes
	Model 1		Model 2		Model 1		Model 2
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Body mass index (per 1-SD higher)	1.06 (0.83, 1.35)	0.64	1.03 (0.80, 1.32)	0.82	1.06 (0.90, 1.26)	0.47	1.05 (0.88, 1.25)	0.59
Waist circumference (per 1-SD higher)	1.08 (0.86, 1.35)	0.53	1.06 (0.83, 1.33)	0.66	1.05 (0.88, 1.26)	0.58	1.04 (0.86, 1.26)	0.68
Fat mass (per 1-SD higher)	1.07 (0.84, 1.36)	0.57	1.05 (0.82, 1.33)	0.71	1.04 (0.87, 1.24)	0.69	1.04 (0.86, 1.25)	0.72

Separate multivariable-adjusted Fine-Gray models were constructed for each adiposity measure and heart failure with sequential adjustment for the following covariates: Model 1 = age, sex, race, alcohol use, smoking history, study cohort; Model 2 = Model 1 covariates plus history of coronary heart disease, history of hypertension, systolic blood pressure, estimated glomerular filtration rate, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride level, statin use.

Abbreviations: CI, confidence interval; HR, hazard ratio; SD, standard deviation