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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Dec 2;42(2):113–126. doi: 10.1161/ATVBAHA.121.316090

Figure 2: Macrophage-specific IGF-1 overexpression reduced atherosclerosis.

Figure 2:

Macrophage-specific IGF-1 overexpressing (MF-IGF1 mice) and control mice (Con) were fed with a high-fat diet. A, C. Enface analysis of atherosclerotic burden (N=30–37 mice per group). B, D. H&E stained cross-sectional aortic valve sections to assess lesional area (N=16–29 mice per group). B Insert: magnified view of lesions showing that plaque in MF-IGF1 mice is less cellular. Scale bar, 100 μm. E. Necrotic core area in atherosclerotic plaque (N=14–15 mice per group). All statistical tests are Student’s two-tailed t-test.