Table 4.
Comparison of disease characteristics in cases with and without a history of autoimmune disease.
| Characteristic | Any Autoimmune Disease N = 117 |
No Autoimmune Disease N = 278 |
|
|---|---|---|---|
| N (%) | N (%) | aOR1 (95% CI) | |
| Sex | |||
| Female | 64 (54.7) | 77 (27.7) | 3.25 (2.01–5.24) |
| Male | 53 (45.3) | 201 (72.3) | Ref |
| Age at diagnosis (years) | |||
| ≤50 | 2 (2.5) | 7 (2.5) | 1.32 (0.29–5.99) |
| 50 – 59 | 11 (9.4) | 25 (9.0) | 1.01 (0.42–2.41) |
| 60 – 69 | 30 (25.6) | 76 (27.3) | Ref |
| 70 – 79 | 52 (44.4) | 99 (35.6) | 1.29 (0.72–2.31) |
| ≥80 | 21 (17.9) | 71 (25.5) | 0.75 (0.38–1.48) |
| Cytogenetics | |||
| Abnormal | 67 (58.3) | 139 (53.8) | 1.05 (0.65–1.68) |
| Normal | 48 (41.7) | 120 (46.2) | Ref |
| WHO Disease Subtype (MDS) | |||
| RA/RN/RT/RARS | 24 (20.5) | 48 (17.3) | 1.21 (0.61–2.38) |
| RCMD | 30 (25.6) | 74 (26.6) | 1.23 (0.67–2.72) |
| RAEB 1/2 | 34 (29.1) | 93 (33.5) | Ref |
| Therapy related | 14 (12.0) | 25 (9.0) | 1.30 (0.57–2.94) |
| MDS with del 5q | 10 (8.6) | 17 (6.1) | 1.05 (0.41–2.69) |
| MDS-U | 5 (4.3) | 21 (7.6) | 0.57 (0.19–1.72) |
| IPSS-R | |||
| Very low/Low | 52 (47.3) | 106 (41.4) | Ref |
| Intermediate | 18 (16.4) | 60 (23.4) | 0.58 (0.30–1.13) |
| High/Very high | 40 (36.4) | 90 (35.2) | 0.90 (0.52–1.57) |
| Missing | 29 |
aOR = adjusted odds ratio; BMI: body mass index; CI = confidence interval; HS: high school; MDS: myelodysplastic syndrome; NSAID: nonsteroidal anti-inflammatory drug.
1
ORs adjusted for age (continuous), sex, education (≤HS grad, some post HS, college grad), NSAID use, exposure to benzene, BMI 2 years ago (<25.0, 25.0–29.9, ≥30.0 kg/m2)