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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Dec 9;42(2):175–188. doi: 10.1161/ATVBAHA.121.317197

Figure 4. Gene Expression in Mouse BM-Mono Exposed to Hypoxia.

Figure 4.

Mouse BM-Mono were exposed or not to 24h hypoxia followed by 4 days in normoxia. qPCR was performed to quantify the gene expression of GLUT-1 and several epigenetic enzymes. (A) GLUT-1 expression was up-regulated in 24h hypoxia. Histone-modifying epigenetic enzymes were significantly down-regulated (B) HDAC7 and (C) KDM1A, while others were up-regulated (KDM3A, KDM3B, and KDM4B) in 24h hypoxia as compared to 24h normoxia. Several histone-modifying epigenetic enzymes were also significantly regulated in 5d normoxia and 4d after 24h hypoxia groups. The data were analyzed by Kruskal-Wallis test followed by Dunn’s multiple comparisons test. Values are median and 95% CI.