Table 2.
Diagnostic accuracy of the SENTIFIT-FOB Gold assay at different cutoffs.
| Coloscopy finding | Cutoff [μg Hb/g] | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|---|
| CRC | 10 | 96.2 (81.1-99.3) | 51.8 (43.5-60.0) | 27.5 (23.9-31.5) | 98.6 (91.1-99.8) |
| 15 | 96.2 (81.1-99.3) | 57.7 (49.3-65.6) | 30.2 (26.0-34.8) | 98.8 (92.0-99.8) | |
| 20 | 96.2 (81.1-99.3) | 60.6 (52.2-68.4) | 31.6 (27.1-36.6) | 98.8 (92.4-99.8) | |
| 30 | 92.3 (75.9-97.9) | 67.2 (58.9-74.5) | 34.9 (29.1-41.1) | 97.9 (92.3-99.4) | |
| 40 | 88.5 (71.0-96.0) | 69.3 (61.2-76.4) | 35.5 (29.2-42.3) | 96.9 (91.5-98.8) | |
| 50 | 88.5 (71.0-96.0) | 72.3 (64.2-79.1) | 37.8 (31.0-45.2) | 97.0 (91.9-99.0) | |
| 100 | 80.8 (62.1-91.5) | 75.9 (68.1-82.3) | 39.0 (31.0-47.6) | 95.4 (90.4-97.9) | |
| 150 | 57.7 (38.9-74.5) | 83.2 (76.1-88.5) | 39.6 (28.5-51.8) | 91.2 (86.8-94.2) | |
| CRC + AA | 10 | 84.6 (72.5-92.0) | 57.7 (48.4-66.4) | 48.5 (42.4-54.6) | 88.8 (80.5-93.9) |
| 15 | 82.7 (70.3-90.6) | 64.0 (54.7-72.3) | 51.9 (45.0-58.8) | 88.7 (81.0-93.5) | |
| 20 | 78.8 (66.0-87.8) | 65.8 (56.5-73.9) | 51.9 (44.7-59.2) | 86.9 (79.4-91.9) | |
| 30 | 71.2 (57.7-81.7) | 71.2 (62.1-78.8) | 53.7 (45.3-62.0) | 84.0 (77.1-89.1) | |
| 40 | 65.4 (51.8-76.8) | 72.1 (63.1-79.6) | 52.4 (43.5-61.2) | 81.6 (75.0-86.7) | |
| 50 | 61.5 (48.0-73.5) | 73.9 (65.0-81.1) | 52.6 (43.1-61.8) | 80.3 (74,0-85.4) | |
| 100 | 57.7 (44.2-70.1) | 78.4 (69.8-85.0) | 55.7 (45.1-65.7) | 79.7 (73.9-84.6) | |
| 150 | 44.2 (31.6-57.7) | 86.5 (78.9-91.6) | 60.6 (46.8-73.0) | 76.7 (71.9-80.9) |
Sensitivity, specificity, PPV (positive predictive value) and NPV (negative predictive value) are shown as percentages with 95% CI. CRC (colorectal cancer), AA (advanced adenoma).