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Response of postmortem brain lysates to 4-HNE. Homogenates were pretreated with 4-HNE for 1 h at the indicated concentrations, followed by measurement of complex I (A,E), II (B,F), III (C,G), and IV (D,H) substrate linked respiration (OCR), with (E-H) and without (A-D) normalization to CS activities. Linear regression was used to determine the R2 value for complex I. (I) Log regression was used to calculate IC50. Data are displayed as the mean ± S.E.M.
