Table 3.
S. No | Function | miRNAs | Targeted Gene | References |
---|---|---|---|---|
1 | Innate Immune response | miR-155 | SHIP1 and TAB2 | [93] |
miR-146a | IRAK-1/TRAF-6 | [94] | ||
miR-21 | PDCD4 | [95] | ||
miR-9 | NFkB1 | [96] | ||
miR-125b | ERK1 | [97] | ||
miR-26-5p | KLF4 | [98] | ||
miR-132-3p | TLR | [99] | ||
2 | Regulation of inflammation | miR-21-5p | TLR4 | [100] |
miR-146a-5p | TRAF-6 | [101] | ||
miR-20b-5p | NLRP3 | [102] | ||
miR-223-3p | NFIA | [103] | ||
miR-27b-3p | Bag2 | [104] | ||
miR-99b-5p | TNF-α and TNFRSF-4 | [105] | ||
miR-125-5p | TNF-α | [106] | ||
miR-142-3p | N-Wasp | [107] | ||
miR-144 | INF-γ and TNF-α | [81] | ||
miR-27a | IRAK4 | [108] | ||
3 | Autophagy | miR-155 | Rheb | [109] |
miR-27a | Cacna2d3 | [110] | ||
miR-889 | TWEAK | [111] | ||
miR-106a | ULK1, ATG7, ATG16L1 | [112] | ||
miR-125 | DRAM2 | [113] | ||
miR-142-3p | ATG16L1 | [114] | ||
miR-17 | ATG7 | [115] | ||
miR-144-3p | ATG4a | [116] | ||
miR-20a | ATG7 and ATG16L1 | [117] | ||
miR-23a-5p | TLR2/MyD88/NF-κB | [118] | ||
miR-26a | KLF4 | [98] | ||
4 | Apoptosis | miR-155 | FOXO3 | [119] |
miR-20a-5p | JNK2 | [120] | ||
miR-27b | Bag2 | [104] | ||
miR-145 | cIAP1 | [121] | ||
Let-7e | Caspase 3 | [122] | ||
miR-29a | Caspase 7 | [123] | ||
miR-21 | PI3/AKT/NFkB | [124] |