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. 2022 Jan 1;7(1):16–26. doi: 10.1016/j.ncrna.2021.12.005

Table 3.

Summary of the role of miRNAs in the pathogenesis of tuberculosis.

S. No Function miRNAs Targeted Gene References
1 Innate Immune response miR-155 SHIP1 and TAB2 [93]
miR-146a IRAK-1/TRAF-6 [94]
miR-21 PDCD4 [95]
miR-9 NFkB1 [96]
miR-125b ERK1 [97]
miR-26-5p KLF4 [98]
miR-132-3p TLR [99]
2 Regulation of inflammation miR-21-5p TLR4 [100]
miR-146a-5p TRAF-6 [101]
miR-20b-5p NLRP3 [102]
miR-223-3p NFIA [103]
miR-27b-3p Bag2 [104]
miR-99b-5p TNF-α and TNFRSF-4 [105]
miR-125-5p TNF-α [106]
miR-142-3p N-Wasp [107]
miR-144 INF-γ and TNF-α [81]
miR-27a IRAK4 [108]
3 Autophagy miR-155 Rheb [109]
miR-27a Cacna2d3 [110]
miR-889 TWEAK [111]
miR-106a ULK1, ATG7, ATG16L1 [112]
miR-125 DRAM2 [113]
miR-142-3p ATG16L1 [114]
miR-17 ATG7 [115]
miR-144-3p ATG4a [116]
miR-20a ATG7 and ATG16L1 [117]
miR-23a-5p TLR2/MyD88/NF-κB [118]
miR-26a KLF4 [98]
4 Apoptosis miR-155 FOXO3 [119]
miR-20a-5p JNK2 [120]
miR-27b Bag2 [104]
miR-145 cIAP1 [121]
Let-7e Caspase 3 [122]
miR-29a Caspase 7 [123]
miR-21 PI3/AKT/NFkB [124]