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. 2022 Jan 13;12:774346. doi: 10.3389/fendo.2021.774346

Table 6.

Variables associated with severe COVID-19 outcomes in the final model of the multivariable stepwise logistic regression analysis.

Variables Adjusted OR (95% CI) P-value
NTIS 3.64 (1.49 – 8.91) 0.005
Male (vs female) 2.20 (1.05 – 4.61) 0.037
IHD/CHF 3.23 (0.91 – 11.5) 0.070
Stroke/TIA 5.49 (1.32 – 22.9) 0.019
Ct value <25 3.34 (1.47 – 7.58) 0.004
Elevated CRP 3.70 (1.51 – 9.10) 0.004
Hypoalbuminaemia 2.12 (0.92 – 4.89) 0.078
Elevated creatine kinase 2.28 (0.95 – 5.45) 0.065

NTIS, non-thyroidal illness syndrome; IHD, ischaemic heart disease; CHF, congestive heart failure; TIA, transient ischaemic attack; Ct, cycle threshold; CRP, C-reactive protein.

The model included NTIS, lymphopenia, age >50 years, male, hypertension, diabetes, obesity, IHD/CHF, stroke/TIA, symptomatic presentation, Ct value <25, hypoalbuminaemia, hyponatraemia, elevated urea, estimated glomerular filtration rate <60 mL/min, elevated aspartate aminotransferase, elevated lactate dehydrogenase, elevated creatine kinase and elevated troponin T.

Values in bold represent statistical significance.