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. 2022 Jan 13;11:784096. doi: 10.3389/fonc.2021.784096

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Copyright © 2022 Wang, Zeng, Wang, Liu, Lu and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association of the candidate gene set with brain metastasis-free survival of breast cancer patients and effects of the genes on migration of 231-BR cells. (A) The association between the candidate gene set and brain metastasis-free survival in breast cancer patients. Samples were obtained from the GEO database. The P value was calculated by log rank test. (B) Knockdown of KRT19, FKBP10, GSK3B and SPANXB1 inhibited the migration of 231-BR cells as determined by wound healing assay, and the representative images are shown. Bar, 200μm. (C) The quantified data of wound healing assay are shown. Student’s t-test was used for statistical analysis: *P < 0.05, **P < 0.01, ***P < 0.001 compared with corresponding control (shCTRL) at the same time point. (D) Knockdown efficiency of shRNAs was verified by quantitative RT-PCR. Student’s t-test was used for statistical analysis: ***P < 0.001 compared with shCTRL.