TABLE 5.

Simple effects results of variance analysis of the PI3K-AKT1 signaling pathway in rats.

Time (day)	Dosage (mg/kg)		PI3K p85		PTEN		PDK1		AKT		NF-κB
	MT	MP	F	P	F	P	F	P	F	P	F	P
1	0 or 15	15	172.30	<0.0001	42.46	<0.0001	500.68	<0.0001	25.61	<0.0001	1.48	= 0.2287
3	0 or 15	15	140.20	<0.0001	46.47	<0.0001	89.11	<0.0001	0.50	= 0.4813	996.04	<0.0001
7	0 or 15	15	507.51	<0.0001	59.25	<0.0001	171.96	<0.0001	20.07	<0.0001	1,275.70	<0.0001
14	0 or 15	15	971.73	<0.0001	136.70	<0.0001	560.73	<0.0001	213.15	<0.0001	53.54	<0.0001
1	15	0 or 15	267.06	<0.0001	8.67	= 0.005	678.77	<0.0001	82.23	<0.0001	0.23	= 0.6311
3	15	0 or 15	252.25	<0.0001	88.24	<0.0001	310.66	<0.0001	6.27	= 0.0158	1,235.33	<0.0001
7	15	0 or 15	727.88	<0.0001	150.10	<0.0001	247.72	<0.0001	86.04	<0.0001	1885.50	<0.0001
14	15	0 or 15	1,277.44	<0.0001	189.20	<0.0001	1,021.60	<0.0001	290.17	<0.0001	132.66	<0.0001