TABLE 2.

Minimum intervention or combination that can achieve malaria elimination in each target location within 15 years after adding driving‐Y mosquitoes into the simulated scenarios

Province	The minimal intervention(s) that could achieve malaria elimination
Nord Kivu	Elimination is possible with interventions at pre‐existing levels.
Intervention	ITNs			ACT			ITNs+ACT
Coverage	50%	80%	95%	50%	80%	95%	50%	80%	95%
Haut Katanga	1.0	0.95	0.95	1.0	1.0	0.95	0.95	NA	NA
Kwango	1.0	1.0	0.95	1.0	1.0	1.0	1.0	0.95	NA
Kasai Central	1.0	1.0	0.95	1.0	1.0	1.0	1.0	0.95	NA
Nord Ubangui	1.0	1.0	0.95	1.0	1.0	1.0	1.0	0.95	NA
Bas Uele	1.0	1.0	1.0	1.0	1.0	1.0	1.0	0.95	0.9
Kinshasa	1.0	1.0	1.0	1.0	1.0	1.0	1.0	0.95	0.9
Equateur	1.0	1.0	1.0	1.0	1.0	1.0	1.0	0.95	0.9

When gene drives were applied, multiple X‐shredder efficiencies were simulated. The X‐shredder efficiency in the table is the lowest X‐shredder efficiency that could result in malaria elimination. Orange color: malaria elimination without gene drives. Blue color: malaria elimination with gene drives. 1.0: gene drives with X‐shredder efficiency = 1.0. 0.95: gene drives with X‐shredder efficiencies = 0.95 and 1.0. 0.9: gene drives with X‐shredder efficiencies = 0.9, 0.95 and 1.0.

Abbreviations: ACT, case management rate with artemisinin‐based combination treatment (Artemether + Lumefantrine); ITNs, insecticide‐treated nets; NA, not applicable, gene drives were not applied in the scenarios because malaria elimination was achieved with the indicated intervention combination without gene drives.