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. 2022 Jan 17;32(1):46–53. doi: 10.1089/thy.2021.0040

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© Salvatore Monti et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — ACTH (250 μg) stimulation test of all 13 patients treated with lenvatinib at baseline (0, before starting therapy) and during follow-up (3, 6, 9, 12, 15, 18, 21, 24, and 27 months). Seven patients (#4, #6, #8, #9, #10, #11, and #12) had an insufficient response (cortisol peak <500 nmol/L) indicating adrenal insufficiency. After 12 months of treatment, PAI patient #6 interrupted lenvatinib for 34 days and ACTH stimulation was normal; after lenvatinib restarted, a recurrence of PAI (cortisol peak <500) was demonstrated (see Results). ACTH, adrenocorticotropic hormone; PAI, primary adrenal insufficiency. Color images are available online.