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. 2022 Jan 13;8:780123. doi: 10.3389/fcvm.2021.780123

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Copyright © 2022 Zhou, Liu, Zou, Zou, Zhang, Cao, Liu, Yuan, Huang, Ma and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of sphingolipid metabolism in Tetralogy of Fallot (TOF). (A) Lipid metabolic process was significantly enriched in the GSE132176 dataset by the gene set enrichment analysis (GSEA). (B) Lipid metabolic processes were significantly enriched in the GSE141955 dataset by the GSEA. (C,D) Sphingolipid metabolism was significantly downregulated in TOF compared with atrial septal defects (ASDs) by the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome analyses, while sphingolipid transfer activity and the sphingolipid biosynthetic process were not significantly different. (E,F) Sphingolipid metabolism was significantly downregulated in TOF compared with healthy donors by the KEGG and Reactome analyses, while sphingolipid transfer activity and the sphingolipid biosynthetic process were not significantly different.