Table 2.

Test for interaction on mean annual refraction change by doses of atropine, ethnicity, and study design.

Characteristics	No. of studies	MD (95% CI)	P-interaction
Doses of atropine
High	14	0.73 (0.57, 0.88)
Moderate	12	0.67 (0.31, 1.03)
Low	10	0.35 (0.22, 0.48)
Ethnicity
Asian patients	21	0.65 (0.46, 0.83)	0.006 *
White patients	6	0.39 (0.23, 0.54)
Study design
RCT	18	0.55 (0.43, 0.67)	0.4508†
Cohort studies	19	0.68 (0.36, 1.01)

MD, mean difference. Bold type indicates statistically significant.

^*Test for interaction between doses of atropine and ethnicity on mean annual refraction change.

^†Test for interaction between doses of atropine and study design on mean annual refraction change.