TABLE 1.

Inhibition of the Wnt pathway with the biotransformation products.

Gray/white background highlights compounds with similar scaffold.

*The cell lines used were chosen to represent a broad variety of TNBC histotypes: luminal-like ductal (BT-20), squamous (HCC1806), and adenocarcinoma (MDA-MB-468); basal-like ductal (HCC1395) and adenocarcinoma (MDA-MB-231).

^(a)Compounds are considered inactive and non-toxic if the highest concentration tested does not show a 20% reduction compared to the control.

^(b)Compounds are considered “toxic” if the IC₅₀ value against Renilla luciferase is less than 1.7-fold of the estimated TopFlash one (i.e., SI < 1.7), indicating that the decrease in observed signal in the TopFlash is due to or strongly affected by the toxic effect.