Table 4. Risk of Hospitalization Due to Psychosis Within 12 Months of Follow-up for the Population of Individuals Remaining After Applying Each Specific Exclusion Criterion Separately Compared With Individuals Who Did Not Meet Any Exclusion Criteria (Eligible Group).
| Eligibility | Finnish cohort | Swedish cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of individuals | Relapsed, No. (%) | Time to event/censoring, mean (SD), d | HR (95% CI)a | P value | No. of individuals | Relapsed, No. (%) | Time to event/censoring, mean (SD), d | HR (95% CI)a | P value | |
| Age <18 and >65 y | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 0.71 (0.61-0.83) | <.001 | 1619 | 240 (14.8) | 273 (127) | 1.04 (0.78-1.38) | .80 |
| Ineligible | 1795 | 212 (11.8) | 267 (133) | 403 | 60 (14.9) | 264 (131) | ||||
| Substance use | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.43 (1.29-1.59) | <.001 | 1619 | 240 (14.8) | 273 (127) | 1.88 (1.61-2.21) | <.001 |
| Ineligible | 3808 | 801 (21.0) | 228 (143) | 1828 | 430 (23.5) | 224 (140) | ||||
| Suicide attempt | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.61 (1.42-1.83) | <.001 | 1619 | 240 (14.8) | 273 (127) | 2.13 (1.79-2.54) | <.001 |
| Ineligible | 1690 | 395 (23.4) | 225 (144) | 1032 | 270 (26.2) | 219 (141) | ||||
| Treatment resistance | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.71 (1.52-1.93) | <.001 | 1619 | 240 (14.8) | 273 (127) | 2.31 (1.87-2.85) | <.001 |
| Ineligible | 1805 | 476 (26.4) | 242 (143) | 450 | 134 (29.8) | 233 (141) | ||||
| Serious somatic disease, broader definition | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.09 (0.99-1.20) | .09 | 1619 | 240 (14.8) | 273 (127) | 1.53 (1.31-1.77) | <.001 |
| Ineligible | 7202 | 1247 (17.3) | 252 (138) | 2866 | 586 (20.5) | 243 (139) | ||||
| Serious somatic disease, narrower definition | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.10 (0.99-1.22) | .08 | 1619 | 240 (14.8) | 273 (127) | 1.58 (1.34-1.86) | <.001 |
| Ineligible | 5087 | 877 (17.2) | 247 (139) | 1747 | 361 (20.7) | 236 (138) | ||||
| Mood stabilizer/antidepressant concomitant use | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.10 (1.01-1.22) | .03 | 1619 | 240 (14.8) | 273 (127) | 1.51 (1.30-1.75) | <.001 |
| Ineligible | 7983 | 1456 (18.2) | 262 (135) | 3281 | 682 (20.8) | 251 (136) | ||||
| Intellectual disability | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 0.98 (0.79-1.21) | .83 | 1619 | 240 (14.8) | 273 (127) | 1.19 (0.87-1.62) | .28 |
| Ineligible | 622 | 102 (16.4) | 269 (133) | 282 | 47 (16.7) | 257 (133) | ||||
| Tardive dyskinesia | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 1.77 (0.95-3.31) | .07 | 1619 | 240 (14.8) | 273 (127) | 2.13 (1.36-3.32) | <.001 |
| Ineligible | 40 | 10 (25.0) | 211 (137) | 75 | 21 (28.0) | 235 (129) | ||||
| Pregnant or breastfeeding women | ||||||||||
| Eligible | 3580 | 615 (17.2) | 278 (130) | 0.87 (0.55-1.37) | .55 | 1619 | 240 (14.8) | 273 (127) | 1.29 (0.53-3.13) | .57 |
| Ineligible | 143 | 19 (13.3) | 240 (145) | 30 | 5 (16.7) | 237 (148) | ||||
Abbreviation: HR, hazard ratio.
a
An HR >1 means higher risk in the ineligible group.