The inhibitors targeting the bottom pocket of the EED protein and their related research.

Compound	Sequence or structure	Selectivity and binding	Associated tumor type	Publication year	Ref.
SAH-EZH2	FSSNRXKILXRTEILNQEWKQRRIQPV	(1) Selective inhibition for PRC2	(1) DLBCL with EZH2 mutations: Karpas422, Pfeiffer	2014	69
		(2) Binding to EED with KD = 0.32 nM	(2) Breast cancer: MDA-MB-231
			(3) Prostate cancer: DU145
			(4) Leukemia: MLL-AF9
Astemizole		(1) Selective inhibition for PRC2	DLBCL containing EZH2 mutations and WT EZH2: SU-DHL4, SU-DHL6, DB, Pfeiffer; Toledo	2014	72
		(2) Binding to EED with ΔTm >4 °C
Wedelolactone		Binding to EED with KD = 2.82 μM	(1) Hepatocellular lines HepG2	2015	77
			(2) Monocytic leukemia cells THP1
			(3) Myeloid leukemia cells K562
DC-PRC2in-01		(1) Selective inhibition for PRC2	DLBCL with EZH2 mutations: SU-DHL4, DB, Pfeiffer, Karpas422	2021	73
		(2) Binding to EED with KD = 4.56 μM