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. 2022 Jan 26;5(1):e2145179. doi: 10.1001/jamanetworkopen.2021.45179

Table 4. Cox Proportional Hazards Models for 30-Day Mortality, by Shock Etiology.

Variables HR (95% CI)a
All Cardiogenic shock Septic shock Hypovolemic shock Other
Age 1.04 (1.03-1.04)b 1.02 (1.02-1.03)b 1.03 (1.03-1.04)b 1.04 (1.03-1.05)b 1.05 (1.04-1.05)b
Female sex 1.00 (0.93-1.07) 1.26 (1.12-1.42)b 0.93 (0.83-1.04) 0.84 (0.68-1.05) 0.87 (0.73-1.04)
Prior coronary disease 0.86 (0.79-0.94)b 0.93 (0.81-1.06) 0.89 (0.76-1.03) 0.63 (0.46-0.86)b 1.04 (0.82-1.31)
Hypertension 0.78 (0.72-0.84)b 0.79 (0.70-0.89)b 0.76 (0.67-0.86)b 0.90 (0.71-1.14) 0.80 (0.66-0.97)c
Chronic kidney disease 1.25 (1.10-1.42)b 1.20 (0.95-1.50) 1.16 (0.95-1.42) 1.62 (1.13-2.31)b 1.38 (0.97-1.96)d
Prior heart failure 1.21 (1.09-1.33) 1.28 (1.09-1.51)b 1.12 (0.96-1.32) 1.06 (0.75-1.51) 1.42 (1.10-1.84)b
CVA 1.16 (1.04-1.30)c 1.22 (1.0-1.50)c 1.05 (0.87-1.25) 1.41 (1.00-1.99)d 1.16 (0.88-1.54)
COPD 1.15 (1.04-1.27)b 1.21 (1.02-1.45)c 0.87 (0.74-1.02)d 1.28 (0.90-1.83) 1.23 (0.94-1.60)
Initial systolic BP 0.99 (0.99-0.99)b 0.99 (0.99-1.00)b 0.99 (0.99-0.99)b 0.99 (0.99-1.00)b 0.99 (0.99-0.99)b
Initial heart rate 1.01 (1.00-1.01)c 1.01 (1.00-1.01)b 1.01 (1.00-1.01)b 1.01 (1.00-1.01)b 1.01 (1.00-1.01)b
Prehospital intubation 3.93 (3.48-4.44)b 2.49 (1.91-3.24)b 2.53 (1.83-3.51)b 6.91 (3.56-13.44)b 5.62 (4.12-7.65)b
Prehospital cardiac arreste NA 2.41 (1.82-3.19)b NA NA NA
Socioeconomic statusf 0.96 (0.94-0.98)b 0.94 (0.90-0.98)b 1.00 (0.96-1.04) 0.97 (0.89-1.05) 0.96 (0.90-1.02)

Abbreviations: BP, blood pressure; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; HR, hazard ratio; NA, not applicable.

a

HRs represent time-to-death analysis using a Cox regression model. Individual analyses were performed for each etiology.

b

P < .01.

c

P < .05.

d

P < .10.

e

Prehospital cardiac arrest as determined by the Victorian Ambulance Cardiac Arrest registry was included as a covariate in the model for cardiogenic shock.

f

Socioeconomic status uses Index of Relative Socioeconomic Disadvantage decile.