TABLE 4.

Follow-up of the patients with primary HIV-1 infection

Patient no.a	Follow-up	Proviral HIV-1 DNA (copies/106 PBMC) at:		QCVc (IU/106 PBMC)	Plasma HIV-1 RNA (copies/ml)	No. of cells/mm3
		60°C	65°Cb			CD4+	CD8+
1	D0	1,342	1,025	32.9	>750,000	621	1,454
	M1	362	449	<0.1	1,208	620	456
	M6	146	116	<0.1	72	501	571
	M12	44	25	<0.1	<50	645	685
2	D0	923	0	166.3	>750,000	813	745
	M1	212	0	<0.1	NDd	859	756
	M6	48	0	<0.1	<50	704	558
	M12	21	0	<0.1	<50	887	684
3	D0	676	331	2.9	57,161	417	1,124
	M1	288	355	3.1	324	463	748
	M6	147	91	<0.1	<50	658	559
	M12	0	<10	<0.1	<50	650	619
4	D0	436	105	24.2	52,674	438	1,826
	M1	369	27	0.6	940	659	1,070
	M6	175	9	<0.1	<50	828	1,118
	M12	72	10	<0.1	<50	758	778
5	D0	266	<10	ND	128,100	663	743
	M4	0	<10	<0.1	ND	831	648
	M6	20	<10	<0.1	105	985	788
	M12	<10	0	<0.1	<50	1,216	998
6	D0	259	0	32.9	404,906	258	1,632
	M1	210	0	2.1	11,251	604	1,203
	M6	159	0	<0.1	<50	711	979
	M12	38	0	<0.1	<50	760	925
7	D0	155	<10	16.2	181,988	502	441
	M1	32	<10	0.3	3,552	740	332
	M6	12	<10	<0.1	<50	738	258
	M12	<10	19	<0.1	<50	1,003	404
8	D0	105	26	ND	46,029	ND	ND
	M1	30	<10	<0.1	284	485	798
	M6	<10	<10	<0.1	<50	546	693
	M12	0	<10	<0.1	<50	637	986
9	D0	10	<10	2.5	89,049	367	454
	M3	0	<10	<0.1	<50	177	130
	M6	<10	<10	<0.1	<50	582	466
	M15	0	<10	<0.1	<50	590	407
10	D0	9,182	ND	35.0	>750,000	261	1,783
	M12	53	ND	<0.1	<50	508	381
11	D0	1,168	ND	32.9	57,480	543	625
	M12	358	ND	<0.1	178	746	723
12	D0	963	ND	24.2	100,740	306	1,193
	M12	245	ND	<0.1	<50	454	861
13	D0	707	ND	9.1	139,120	534	1,595
	M12	108	ND	<0.1	75	661	610
14	D0	466	ND	17.0	178,000	238	938
	M12	10	ND	<0.1	<50	188	776
15	D0	143	ND	24.2	254,400	600	3,186
	M12	38	ND	<0.1	<200	1,113	1,089
16	D0	42	ND	24.0	28,960	270	450
	M12	16	ND	<0.1	<50	505	355

^aPatients 1 to 9 were treated with lamivudine, stavudine and indinavir and patients 10 to 16 were treated with zidovudine, lamivudine and didanosine and monitored as described in Materials and Methods. 

^bFor patients 1 to 9, proviral HIV-1 DNA was also quantified with a PCR annealing temperature of 65°C, instead of 60°C. 

^cQCV, quantitative cellular viremia. 

^dND, not determined.