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. 2022 Jan 13;12:802463. doi: 10.3389/fendo.2021.802463

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Copyright © 2022 Wang, Bo, Liang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC00467 upregulation is modulated by promoter methylation in LUAD. (A) Mean methylation levels of the LINC00467 promoter in tumor versus normal tissues in the TCGA LUAD cohort. (B) Heatmap of LINC00467 expression and DNA methylation in TCGA LUAD cohort. (C) LINC00467 expression negatively correlates with mean LINC00467 promoter methylation levels in TCGA LUAD cohort. (D) LINC00467 expression in A549 cells was significantly down-regulated in a dose-dependent manner after 5-azacytidine treatment.