TABLE I.
Membrane binding properties of FP23.
| Sample | aNExtra, e− | b φ | cAFP23, Å2 | dΔG, kcal mol −1 |
|---|---|---|---|---|
| DPPC + FP23 | 163.6 | e5.3 | 245 | e−8.05 |
| DPPC/Chol(87:13) + FP23 | 302.1 | 5.8 | 210 | −8.02 |
| DPPC/Chol(75:25) + FP23 | 266.5 | 6.5 | 180 | − 8.00 |
| DPPC/Chol(54:46) + FP23 | 165.7 | 10.5 | 180 | −7.79 |
a
NExtra is a number of FP23 electrons in the volume occupied by a single lipid molecule.
b
φ denotes the equilibrium lipid-to-peptide ratio in the monolayers.
c
A FP23 is the area per FP23 monomer within a film.
d
ΔG-Gibbs free energy of FP23 binding to the monolayers.
e
This value accounts for the fact that only 50% of DPPC molecules interact directly with FP23.