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. 2022 Jan 13;12:815245. doi: 10.3389/fendo.2021.815245

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Copyright © 2022 Deng, He, Cai, Jiang, Yang, Dan, Luo, Du, Chen and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of differentially expressed genes (DEGs) with the cut off criteria of P-Value <0.05. (A) Volcano plot of DEGs for GSE2208 datasets. (B) Volcano plot of DEGs for GSE56815 datasets. (C) The heatmap of top 40 (20 upregulated DEGs and 20 downregulated DEGs) DEGs according to RRA algorithm. As the color goes from red to blue, indicating the changing from up to downregulation. NA represents genes with no statistical significance in GSE2208, but it can be reflected in RRA algorithm because of its high ranking and small P value in GSE56815. Similar results can be referenced in https://doi.org/10.3389/fonc.2019.00996.