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. 2022 Jan 13;12:815245. doi: 10.3389/fendo.2021.815245

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Copyright © 2022 Deng, He, Cai, Jiang, Yang, Dan, Luo, Du, Chen and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The highly connected modules of PPI and the correlation matrix corresponding to each module. (A–C) Modules of PPI network. (D–F) Correlation matrixes of highly connected genes in each module. In the modules, red represents genes that are upregulated and blue represents genes that are downregulated. In the correlation analysis, blue indicates positive correlations, red indicates negative correlations, and higher values indicate higher correlations. Squares marked with a cross indicate that the correlation analysis between genes is not statistically significant (P > 0.05).