Figure 2.
Effect on retinal function of LBE oral feeding started at different ages. LBE feeding started at 4 months or 6 months of age in both non-Tg and 3xTg-AD mice. For two months, two doses [low (200 mg/kg) or high (2 g/kg)] of LBE were given daily, while water served as the control and non-feeding as the age-matched AD control. LBE feeding from age 4 months showed a trend toward better scotopic retinal response for both a-wave and b-wave in 3xTg-AD mice (A). When started at 6 months of age, high dose LBE feeding of 3xTg-AD mice for 1 month showed significantly higher retinal response to scotopic light intensity (3.0 cd·s/m2) compared to 3xTg-AD mice given only water (C). Photopic b-wave and PhNR, indicating the function of the inner nuclear layer and RGCs, showed no differences among all the groups (B,D). *p < 0.05, **p < 0.01; NS, no significant change. Typical ERG wave forms of various groups at 1 month and 2 months after the start of feeding (E).