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. 2022 Jan 13;13:788798. doi: 10.3389/fnagi.2021.788798

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Copyright © 2022 Liu, Baum, Yu, Lin, Xiong, Chang, So and Chiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two months LBE oral feeding downregulated expression of 8-OHG, calpain-2, and calpain-5 in 3xTg-AD mice at the age of 8 months. (A) Representative images of 8-OHG, calpain-2, and calpain-5 stained retinal sections of 3xTg-AD mice and age matched non-Tg control mice fed with water, low dose LBE or high dose LBE. Semi-quantification analysis showed increased 8-OHG (B), calpain-2 [(C), * P < 0.05; ** P < 0.01], and calpain-5 [(D), * P < 0.05; **P < 0.01] in the retinas of 3xTg-AD mice, which could be suppressed by LBE feeding.