Figure 4.

LBE oral feeding significantly preserved presynaptic terminals in 3xTg-AD mice at 8 months of age. (A) Representative images of retinal sections stained for the presynaptic marker, synaptophysin, in 8 month old 3xTg-AD mice and age matched non-Tg control mice fed with water, low dose LBE or high dose LBE. Semi-quantification analysis revealed decreased presynaptic densities in the IPL but not the OPL in 8 month old 3xTg-AD mice, and rescue of the decrease by high dose LBE feeding [(B), * P < 0.05, **p < 0.01]. Representative images of retinal sections stained for the postsynaptic marker, PSD-95, in 8 month old 3xTg-AD mice and age matched wild type mice fed with water, low dose LBE or high dose LBE (C). No significant changes were observed in postsynaptic densities among all the groups (D).