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. Author manuscript; available in PMC: 2022 Aug 12.
Published in final edited form as: J Med Chem. 2021 Aug 3;64(15):11729–11745. doi: 10.1021/acs.jmedchem.1c01136

Table 1.

Linker SAR.

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a

EC50 values and 95% confidence intervals are calculated from average potency in the Cp HCT-8 assay from at least two 9-point dose-response experiments (n=8 technical replicates per dose). n.d. = not determined.

b

ClogP represents an estimate of lipophilicity and is the log of the partition coefficient as calculated in CDD Vault using the ChemAxon fragment approach (www.collaborativedrug.com).