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In vitro ADME Profiling Data
| Entry | Cmpd | Aq. Sol. pH 7.4, μM | MLM t1/2, min | HLM t1/2, min | MDCK-MDR Efflux Ratio |
|---|---|---|---|---|---|
| 1 | 1 | 200 | >30 | >30 | 8.9 |
| 2 | 2 | 1.8 | >30 | >30 | 12 |
| 3 | 12a | 18 | >30 | >30 | 5.8 |
| 4 | 18a | 59 | - | >30 | 6.5 |
| 5 | 19a | - | - | >30 | 6.6 |
| 6 | 19b | - | - | 7.8 | 9.8 |
| 7 | 29i | 10 | >30 | >30 | 3 |
