Table 3.

Histological data for the Group A (26 patients).

N	cTNM (TNM VIII Eds)	pTNM (TNM VIII Eds)	Virtual surgical planning technique	Type of reconstruction	Resection margins	Vascular embolization	Perineural invasion	Bone invasion	Bone margins	Periosteal margins	Soft tissue margins	Radiological pattern	Adjuvant treatments	F-UP (16–84 months)
1	rT4aN3b	ypT4aN2b	CAMR	FFF	Close	No	Yes	Yes	Negative	Negative	Close (3 mm)	Infiltrative	CRT	DWD
2	rT4N2b	ypT3N0	CAMR	FFF	Negative	No	No	No	Negative	Negative	Negative	Infiltrative	None	NED
3	cT4N2b	pT4aN2b	CAMR	FFF	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Erosive	CRT	NED
4	cT3N3b	pT4aN2b	CAMR	FFF	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	DWD
5	cT3N2b	pT4aN3b	CAMR	FFF	Close	Yes	Yes	Yes	Negative	Negative	Close (1.5 mm)	Infiltrative	CRT	DOD
6	cT4aN1	pT4aN0	CAMR	CRP+PM	Close	No	Yes	Yes	Negative	Negative	Close (4 mm)	Erosive	CRT	NED
7	cT4aN0	pT4aN0	CAMR	FFF	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	NED
8	cT2N2a	pT2N0	CARM	CARM + RFFF	Negative	No	No	No	Negative	Negative	Negative	Erosive	None	NED
9	rT4aN0	ypT4aN0	REP-TECH	MRP+PM	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	NED
10	rM1 (breast cancer)	ypM1	CAMR	FFF	Negative	No	No	Yes	Negative	Negative	Negative	Infiltrative	CT	NED
11	cT4aN2b	pT4aN2c	CAMR	FFF	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	NED
12	rTxN3	yTx N3b	REP-TECH	FFF	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Infiltrative	CRT	DWD
13	cT4aN1	pT4aN2a	CAMR	FFF	Negative	Yes	No	Yes	Negative	Negative	Negative	Infiltrative	CRT	DWD
14	cT4a N0	pT4aN1	REP-TECH	FFF	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	DOD
15	rT4aN0	ypT4aN0	CAMR	FFF	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	NED
16	cT4aN0	pT4aN0	REP-TECH	FFF	Negative	No	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	DWD
17	rT3N1	ypT2N1	CAMR	FFF	Negative	Yes	Yes	No	Negative	Negative	Negative	Erosive	CRT	NED
18	cT4aN2	pT4aN2c	REP-TECH	FFF	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Infiltrative	CRT	DWD
19	rcT4aN1	ypT4aN1	REP-TECH	FFF	Positive	Yes	No	Yes	Negative	Negative	Positive	Infiltrative	CRT	NED
20	cT3N1	pT3N1	REP-TECH	FFF	Negative	No	Yes	No	Negative	Negative	Negative	Infiltrative	CRT	NED
21	rT4aN0	ypT4aN0	CAMR	FFF	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	RT	DOD
22	cT4aN1	pT4aN1	REP-TECH	FFF	Negative	No	No	Yes	Negative	Negative	Negative	Infiltrative	CRT	DWD
23	cT3N0	pT3N0	CARM	CARM + RFFF	Close	No	No	No	Negative	Negative	Close (4 mm)	Erosive	RT	NED
24	rcT4N0	ypT4N0	CAMR	CRP+PL	Close	No	No	Yes	Negative	Negative	Close (4 mm)	Erosive	CRT	NED
25	cT4aN0	pT4aN0	REP-TECH	FFF	Negative	Yes	No	Yes	Negative	Negative	Negative	Infiltrative	RT	DWD
26	cT4aN1	pT4aN3b	CAMR	CRP+PM	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	NED

CARM, computer-assisted rim mandibulectomy; CAMR, computer-assisted mandibular reconstruction; REP-TECH, repositioning technique; FFF, free fibula composite flap (bone + soft tissue); CRP + PM, customized reconstructive plate + pectoralis major flap; MRP + PM, manually pre-shaped reconstructive plate on stereolithographic models + pectoralis major flap; CARM + RFFF, computer assisted rim mandibulectomy + radial forearm free flap; CRT, concurrent chemoradiation; RT, radiotherapy; NED, non-evidence disease; DWD, dead for disease; DOD, dead for other disease.