Table 4.

Histological data for the Group B (21 patients).

N	cTNM (TNM VIII Eds)	pTNM (TNM VIII Eds)	Virtual surgical planning technique	Type of reconstruction	Resection margins	Vascular embolization	Perineural invasion	Bone invasion	Bone margins	Periosteal margins	Soft tissue margins	Radiological pattern	Adjuvant treatments	F-UP (96–180 months)
1	rT4aN3b	ypT4aN2b	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	None	DWD
2	cT4aN1	pT4aN0	Stereolitographic model	FFF + MRP	Negative	No	No	Yes	Negative	Negative	Negative	Infiltrative	RT	NED
3	rT4aN0	ypT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (2 mm)	Infiltrative	None	DWD
4	rT4aN0	ypT4aN0	Stereolitographic model	FFF + MRP	Negative	No	No	Yes	Negative	Negative	Negative	Erosive	None	NED
5	cT4aN0	pT4aN3b	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Positive	Negative	Close (2 mm)	Infiltrative	CRT	DWD
6	rT4aN0	ypT4aN1	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	NED
7	cT4aN2a	pT4aN3b	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	DWD
8	cT4aN1	pT4aN3b	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Negative	Negative	Negative	Infiltrative	CRT	DWD
9	cT4aN1	pT4aN3b	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Infiltrative	CRT	DWD
10	cT4aN0	pT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Negative	Erosive	CRT	DOD
11	cT4aN0	pT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	No	Yes	Negative	Negative	Close (1 mm)	Infiltrative	CRT	NED
12	rT4aN0	ypT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (2 mm)	Erosive	RT	DOD
13	cT4aN1	pT4aN3b	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Positive	Negative	Close (1 mm)	Infiltrative	CRT	DWD
14	cT4aN3b	pT4aNeb	Stereolitographic model	FFF + MRP	Negative	No	No	Yes	Negative	Negative	Negative	Infiltrative	CRT	NED
15	cT4aN0	pT4aN0	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Erosive	RT	DOD
16	rT4aN0	ypT4aN0	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Infiltrative	CRT	DWD
17	cT4aN2a	pT4aN3b	Stereolitographic model	FFF + MRP	Close	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Erosive	CRT	DWD
18	cT4aN3b	pT4aN3b	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (2 mm)	Infiltrative	CRT	DWD
19	cT4aN0	pT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	No	Yes	Negative	Negative	Negative	Infiltrative	CRT	NED
20	rT4aN3b	ypT4aN3b	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (2 mm)	Erosive	CRT	DWD
21	rT4aN0	ypT4aN0	Stereolitographic model	FFF + MRP	Negative	Yes	Yes	Yes	Negative	Negative	Close (1 mm)	Infiltrative	None	DOD

FFF, free fibula composite flap (bone + soft tissue); MRP, manually pre-shaped reconstructive plate on stereolithographic models; CRT, concurrent chemoradiation; RT, radiotherapy; NED, non evidence disease; DWD, dead for disease; DOD, dead for other disease.