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. 2022 Jan 13;9:790544. doi: 10.3389/fpubh.2021.790544

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Copyright © 2022 Nelson, Talarico, Poonja, McDaniel, Cilnis, Chang, Raz, Noboa, Cowan, Shaw, Posey and Silk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between modified case-pair interval and pairwise single nucleotide polymorphism (SNP) difference between genotype-matched source–secondary case pairs in Los Angeles County, California, 2015–2018^a. ^aThe modified case-pair interval is defined as the time between the estimated midpoint of the source patient's TB infectious period and the sample collection date of the secondary patient. Each dot corresponds to a source–secondary case pair. (A) Scatter plot of modified case-pair interval, in years, against pairwise SNP distance. (B) Pairwise SNP differences of case pairs with modified case-pair intervals defined as recent transmission (during the previous 2 years) or reactivation (transmission occurred >2 years ago).