Table 1.
Demographic, molecular, and clinical characteristics of patients in the analytic data set of genotype-matched TB source–secondary case pairs vs. other investigated cases in Los Angeles County, California, 2015–2018.
| Characteristic |
Cases included in case pairs (n = 106) no. (%) |
Other investigated cases (n = 878) no. (%) |
|---|---|---|
| Demographic characteristics | ||
| Sex | ||
| Male | 66 (62) | 581 (66) |
| Female | 39 (37) | 287 (33) |
| Unknown/missing | 1 (1) | 10 (1) |
| Median age (yrs) (IQR) | 39 (22–47) | 50 (34–63) |
| Race/ethnicitya | ||
| Asian | 21 (20) | 292 (33) |
| Black/African American | 5 (5) | 110 (13) |
| Hispanic/Latino | 76 (72) | 428 (49) |
| White | 3 (3) | 35 (4) |
| Unknown/missing | 1 (1) | 10 (1) |
| Birthplaceb | ||
| US-born | 35 (33) | 250 (28) |
| Non-US–born | 70 (66) | 613 (70) |
| Unknown/missing | 1 (1) | 15 (2) |
| TB diagnosis location | ||
| In Los Angeles County | 103 (97) | 852 (97) |
| Outside Los Angeles County | 3 (3) | 26 (3) |
| Molecular characteristics | ||
| Culture status | ||
| Positive | 105 (99) | 843 (96) |
| Negative | 0 | 14 (2) |
| No results reported | 1 (1) | 21 (2) |
| Number of genotype-matched clusters | 44 | 178 |
| Median number of cases (IQR) | 5 (3–8) | 7 (4–12) |
| Minimum number of cases | 2 | 2 |
| Maximum number of cases | 14 | 38 |
| Social characteristics | ||
| Any substance use | 28 (26) | 182 (21) |
| Excess alcohol use during previous yearc | 16 (57) | 137 (75) |
| Injection drug use during previous yearc | 3 (11) | 15 (8) |
| Non-injection drug use during previous yearc | 17 (61) | 86 (47) |
| No reported history of substance use during previous year | 75 (71) | 650 (74) |
| Unknown/missing | 3 (3) | 46 (5) |
| Homelessness | ||
| Homeless during the year before diagnosis | 7 (7) | 120 (14) |
| No known history of homelessness during the year before diagnosis | 98 (92) | 744 (85) |
| Unknown/missing | 1 (1) | 14 (2) |
| Incarceration | ||
| TB diagnosed while patient was incarcerated | 0 | 24 (3) |
| TB diagnosed while patient was not incarcerated | 105 (99) | 844 (96) |
| Unknown/missing | 1 (1) | 10 (1) |
| Clinical characteristics | ||
| HIV testing | ||
| Positive | 1 (1) | 30 (3) |
| Negative | 88 (83) | 656 (75) |
| Not offered | 7 (7) | 66 (8) |
| Refused | 0 (0) | 7 (1) |
| Unknown/missing | 10 (9) | 119 (14) |
| Other | ||
| Immunosuppression other than HIV | 0 | 45 (5) |
| Tumor necrosis factor-α antagonist therapy | 0 | 8 (1) |
| Post-organ transplantation | 0 | 7 (1) |
| Diabetes mellitus | 20 (19) | 231 (26) |
| End-stage renal disease | 1 (1) | 26 (3) |
| Any first line-drug resistance | 4 (4) | 107 (12) |
IQR, interquartile range.
Hispanic/Latino includes all persons with Hispanic/Latino ethnicity. Other categories include persons with non-Hispanic/Latino ethnicity and the respective race.
US-born is based on eligibility for citizenship at birth and includes people born overseas to parents who are US citizens.
Frequencies of patients with excess alcohol use and injection and non-injection drug use reported during the previous year are tabulated among the subset of patients reporting any substance use. These categories of substance use are not mutually exclusive (i.e., a patient with multiple substance use may be counted multiple times).