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. 2022 Jan 10;7(3):2929–2946. doi: 10.1021/acsomega.1c05727

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© 2022 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Impact of YB-11 and YB-16 on the dorsal root ganglion Ca²⁺ influx assessed with in vitro Ca²⁺ imaging. (A) The max Ca²⁺ signal from YB-11 and YB-16 was significantly reduced compared to that from capsaicin (one-way ANOVA P = 0.011). (B) The area under the curve (AUC) Ca²⁺ signal from YB-11 and YB-16 was significantly reduced compared to that from capsaicin (one-way ANOVA P < 0.0001). Dunnett’s multiple comparison *P < 0.05, ****P < 0.0001. Data are shown as mean ± SEM.