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. 2022 Jan 10;7(3):2929–2946. doi: 10.1021/acsomega.1c05727

Figure 12.

Figure 12

Impact of YB-16 and YB-11 on spontaneous behavior following paw infection. (A) Evaluation of the spontaneous licking and biting of the paw after intraplantar injection of YB-16 (5, 15, 45 μg), capsaicin (5, 10 μg), or vehicle for 120 min after injection (two-way ANOVA P < 0.001 main effect treatment, time, and interaction). (B) Total pain-like behavior for YB-16, capsaicin, or vehicle. Capsaicin treatment (10 μg) leads to a significant reduction in pain-like behavior compared to the vehicle control group. (C) Evaluation of the spontaneous licking and biting of the paw after intraplantar injection of YB-11 (10 μg) or vehicle for 120 min after treatment showing main effects of time (mixed-effects model P < 0.05 main effect treatment, time, and interaction). (D) Total pain-like behavior for YB-11 or vehicle showing an increase in spontaneous behavior after YB-11 treatment. **P < 0.01 Dunnett’s multiple comparison. *P < 0.05 t-test. n = 8–10, all groups. Data are shown as mean ± SEM.