Table 1. In Vitro Human TRPV1 Agonistic Activities^a.

compound	EC50 (μM)
capsaicin	0.11 ± 0.021
YB-1	27 ± 3.8
YB-2	0.082 ± 0.015
YB-3	>10
YB-4	0.68 ± 0.12
YB-5	2.0 ± 0.29
YB-6	>10
YB-7	>10
YB-8	1.9 ± 0.23
YB-9	0.96 ± 0.12
YB-10	0.047 ± 0.0075
YB-11	0.012 ± 0.0033
YB-12	0.60 ± 0.069
YB-13	3.1 ± 0.41
YB-14	0.33 ± 0.041
YB-15	0.048 ± 0.0057
YB-16	0.93 ± 0.082
YB-17	1.1 ± 0.29
YB-18	1.0 ± 0.20
YB-19	45 ± 3.3
YB-20	4.9 ± 0.73
YB-21	0.34 ± 0.065
YB-22	0.21 ± 0.052
YB-23	0.30 ± 0.074

^aEC₅₀ data represent mean ± standard error of the mean (SEM) from three independent experiments. Images in Figure 1 show chemical structures for all referenced analogues in Table 1.