Table 5. In Vivo Mouse PK Summary^a.

compound	species	route	dose (mg/kg)	λz (1/h)	T1/2 (h)	Tmax (h)	Cmax (ng/mL)	AUClast (hr ng/mL)	MRT (h)
YB-2	C57BL6 mouse	IV	0.4	4.1	0.17	0.083	123	38	0.16
YB-16b		SubQ	2	0.59	1.2	0.5	104	173	1.2

^aλz: the elimination rate constant; AUClast: area under a concentration of analyte vs time calculated from time zero to the time of the last positive Y value; and MRT: mean residence time.

^bYB-16 is a prodrug and readily converted into YB-11 in vivo; dose (2 mg/kg) was calculated based on YB-11; YB-11 was the target compound in the PK sample analysis.