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. 2022 Jan 13;11:766576. doi: 10.3389/fonc.2021.766576

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Copyright © 2022 Chen, Chang, Huang, Wu, Li, Chen, Huang, Lo, Yu, Tsai, Wu, Tseng, Lin, Jiang, Lee, Jou, Cheong, Hsueh, Chiu, Chen, Chen, Chiang, Tsai, Lin, Wu, Lin and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan-Meier curves of cancer-specific survival (CSS) following adjustment for age, tumor size, preoperative hydronephrosis, middle ureteral, distal ureteral or bladder cuff urothelial carcinoma (UC), multifocal UCs, previous or synchronous bladder UC, lymphovascular invasion (LVI), tumor necrosis, surgical margin, tumor grading, cell type, pathological T and N staging, and surgical approaches of radical nephroureterectomy (RNU). Significant predicting factors for CSS included: (A) age, (B) chronological history of bladder UC, (C) tumor grading, (D) T stage, (E) surgical margin, (F) preoperative hydronephrosis, (H) LVI, and (I) RNU techniques. (G) N staging did not demonstrate significant influence on CSS because the proportion of lymphadenectomy was limited in the present study.