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. 2022 Jan 27;7:26. doi: 10.1038/s41392-022-00884-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Structures of Nsp4 /Nsp5 /Nsp6 and their inhibitors. a Predicted structure of Nsp4 protein. b Overall structure of 3CLpro protein with electrostatic surface and cartoon models. c–f Structures of 3CLpro in complex with N3, calpain inhibitor II (UAW241), α-ketoamide 13b inhibitors, and PF-07321332, respectively. g Predicted structure of Nsp6 protein