Table 2.

Effects of amyloid status and APOE ε4 status on CSF SNAP-25 and Ng levels

Overall Model	SNAP-25				Ng
	F-statistic		p		F-statistic		p
	17.3		< 0.0001		13.6		< 0.0001
Parameter	Estimate	Standard error	tStat	p	Estimate	Standard Error	tStat	p
APOE ε4 carrier	1.30	0.20	6.5	< 0.0001	55.70	133	0.42	N.S.
Amyloid positive	0.69	0.24	2.9	0.004	784	158	4.95	< 0.0001
Age (years)	0.012	0.012	0.98	0.33	23.9	7.87	3.04	0.003
Female sex	−0.24	0.19	−1.24	0.22	62.2	129	0.48	N.S.
Education (years)	−0.06	0.038	−1.58	0.12	−14.2	25.2	−0.56	N.S.
Intercept	4.89	1.14	4.3	< 0.0001	394	762	0.52	N.S.

CSF SNAP-25 and CSF Ng as a function of APOE ε4 carrier status and amyloid status^a, adjusting for age, sex, and years of education. The estimate reflects the pg/mL change in biomarker levels associated with a unit change in the predictor values.

^aAmyloid-negative if CSF ptau181/Aβ₄₂ < 0.0198; Amyloid-positive if CSF ptau181/Aβ₄₂ ≥ 0.0198 (Schindler et al., 2018).