Skip to main content
. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Neurobiol Aging. 2021 Feb 11;102:64–72. doi: 10.1016/j.neurobiolaging.2021.02.008

Table 3.

Effects of Amyloid Status and APOE ε4 status on CSF SNAP-25 and Ng levels (ADNI)

Overall model SNAP-25 Ng
F-statistic p F-statistic p
2.39 0.05 1.93 0.105
Parameter Estimate Standard Error tStat p Estimate Standard Error tStat p
APOE ε4 carrier 0.99 0.44 2.27 0.03 164.25 312.99 0.52 N.S.
Amyloid positive 0.17 0.36 0.48 0.64 423.9 258.14 1.64 N.S.
Age (years) −0.01 0.03 −0.16 0.87 16.26 22.91 0.71 N.S.
Female Sex 0.68 0.38 1.78 0.08 437.14 272.9 1.6 N.S.
Education (years) 0 0.06 −0.07 0.94 7.61 41.88 0.18 N.S.
Intercept 3.61 2.76 1.31 0.2 23.35 1973.57 0.01 N.S.

CSF SNAP-25 and CSF Ng as a function of APOE ε4 carrier status and amyloid statusa, accounting for confounds of age, sex, and years of education for the ADNI dataset. The estimate reflects the pg/mL change in biomarker levels associated with a unit change in the predictor values.

a

Amyloid-negative if CSF ptau181/Aβ42 < 0.0198; Amyloid-positive if CSF ptau181/Aβ42 > 0.0198.