Table 3.
Bivariable and multivariable Cox regression among HIV-positive children on ART at Bahir Dar public health facility Amhara regional state, North West Ethiopia (N = 588) (2010–2019).
| Variables | Category | Status | CHR (95% CI) | AHR (95% CI) | |
|---|---|---|---|---|---|
| Censured N (%) n = 561 |
Death N (%) n = 27 |
||||
| Age of the child | <2 years | 64 (91.4) | 6 (8.6) | 3.5 (1.1, 10.8) | 3.0 (0.8, 11.6) |
| 2–5 years | 96 (95.1) | 5 (4.9) | 1.5 (0.5,4.9) | 0.8 (0.2, 3.2) | |
| 5–10 years | 224 (95.7) | 10 (4.3) | 1.3 (0.5,3.7) | 1.2 (0.4, 3.5) | |
| ⩾10 years | 177 (96.7) | 6 (3.3) | 1 | 1 | |
| Duration between start and eligible date | <7 days | 349 (98.3) | 6 (1.7) | 1 | 1 |
| ⩾7 days | 212 (91) | 21 (9) | 5.0 (2.0, 12.5) | 3.2 (1.2, 8.5)* | |
| Baseline hemoglobin | <8 g/dL | 18 (72) | 7 (28) | 11 (6.7, 18.5) | 3.5 (1.3, 8.9)* |
| ⩾8 g/dL | 534 (96.4) | 20 (3.6) | 1 | 1 | |
| Missing | 7 (1.2%) | 2 (0.3%) | |||
| Initial regimen | NVP based | 352 (93.6) | 24 (6.4) | 1 | 1 |
| EFV based | 168 (99.4) | 1 (0.6) | 0.1 (0.1, 0.7) | 0.2 (0.0, 1.2) | |
| Others | 41 (95.3) | 2 (4.7) | 0.9 (0.2, 3.8) | 0.7 (0.1, 3.8) | |
| Baseline WHO | Stage 1 and 2 | 425 (97.9) | 9 (2.1) | 1 | 1 |
| Advanced | 136 (88.3) | 18 (11.7) | 5.7 (2.6, 12.7) | 3.2 (1.1, 9.4)* | |
| Baseline W/A | ⩾–2z | 482 (97) | 15(3) | 1 | 1 |
| <–2z | 79 (86.8) | 12 (13.2) | 4.3 (2.0, 9.2) | 2.8 (1.2, 6.6)* | |
| Opportunistic infection | Yes | 170 (90.4) | 18 (9.6) | 4.2 (1.9, 9.3) | 1.4 (0.5, 4.3) |
| No | 391 (97.7) | 9 (2.3) | 1 | 1 | |
| Recent adherence | Good | 523 (96.49) | 19 (3.51) | 1 | 1 |
| Fair | 19 (95) | 1 (5) | 1.3 (0.2, 9.8) | 0.8 (0.1, 6.8) | |
| Poor | 19 (73.1) | 7 (26.9) | 7.3 (3.1, 17.5) | 3.9 (1.4, 10.8)* | |
| Recent viral load | <1000 | 459 (97.3) | 13 (2.7) | 1 | 1 |
| ⩾1000 | 71 (88.7) | 9 (11.3) | 4.5 (1.9, 10.5) | 2.0 (0.7, 6.1) | |
| Missing | 31 (86.1) | 5 (13.9) | |||
ART: antiretroviral therapy; CHR: crude hazard ratio; AHR: adjusted hazard ratio; CI: confidence interval; Others in the initial regimen: (ABC-3TC-LPV, TDF-3TC-ATV, and ABC-3TC-LPV); W/A: weight for age; n: number; WHO: World Health Organization; NVP: Nevirapine; EFV: Efavirenz.
*
Significant (p-value < 0.05).