Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 24;21:15330338211070689. doi: 10.1177/15330338211070689

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 1. — Mechanism underlying the initiation of hepatocellular carcinoma (HCC) by BMI1. Previous studies have shown that BMI1 promotes the occurrence of HCC by blocking the INK4a/ARF locus, NF-κB signaling pathway, and TGFβ2/SMAD signaling axis and by stimulating the Wnt/β-catenin signaling axis. Besides, BMI1 and Ras/MAPK signaling work together to activate the initiation of HCC. Black and red arrows represent promotion, T-shaped symbols represent inhibition, and H-shaped symbols represent interactive effects.