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. 2022 Jan 13;12:825358. doi: 10.3389/fimmu.2021.825358

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Copyright © 2022 Xu, Yu, Ye, Gao, Deng, Lu, Lin, Zhang and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Common differential metabolites and proteins. The peak area was used for relative quantification. (A) Venn diagram of differential metabolites of the three compared groups (NC versus NI, NC versus HC, NC versus HI) in positive ion scanning mode; Venn diagram of differential metabolites of the three compared groups in negative ion scanning mode; Venn diagram of differential proteins of the three compared groups. (B) Three of the common differential metabolites. DHT: 5α-dihydrotestosterone. (C) The common differential proteins. TRAP1, TGF-β receptor-associated protein 1; LRG, leucine-rich alpha-2-glycoprotein; UCH19, ubiquitin C-terminal hydrolase 19; PACS1, phosphofurin acidic cluster sorting protein 1; Tox4, TOX high mobility group box family member 4; PSMD10, 26S protein non-ATPase regulatory subunit 10; AU, arbitrary unit. Error bars on graphs indicate mean ± SD.