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. 2022 Jan 13;13:788519. doi: 10.3389/fnagi.2021.788519

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Copyright © 2022 Li, Kitamura, Beverley, Koudelka, Duncombe, Lennen, Jansen, Marshall, Platt, Wiegand, Carare, Kalaria, Iliff and Horsburgh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CSF tracer influx in the perivascular space. (A) Evans blue dye was injected into cisterna magna of a normal mouse. At the surface of the brain, dyes were found distributed along blood vessels, the middle cerebral artery (MCA) and its branches, along the superior sagittal sinus, inferior cerebral vein, and transverse sinus. (B) (Arteriole, in cortical area) and (D) Co-labeling of sections with the vascular basement membrane marker COL4 revealed the localization of CSF fluorescent tracer to the adjacent space. (C) (Capillary, in subcortical area) and (E) Tracer colocalized with the basement membrane. Representative images showing spatial location of tracer soluble lysine fixable dextran 3 kDa (D-3) (green). Scale bar: top (space) = 10 μm, bottom (lumen) = 5 μm.