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. 2022 Jan 13;13:788519. doi: 10.3389/fnagi.2021.788519

FIGURE 7.

FIGURE 7

Vascular pulsatility is reduced in Tg-SwDI animals (A) Two-photon microscopy was used to assess vessel pulsation in sham and post-BCAS WT and Tg-SwDI mice. Four categories of blood vessels were investigated: 1. Pial arteries; 2. Penetrating arteries; 3. Ascending veins; 4. Pial veins. (B) There was a significant effect of genotype on vascular pulsatility in all types of vessels measured, and significant effect of surgery on pial arteries. Post hoc test revealed a significant decrease in vascular pulsation between wild type and Tg-SwDI sham animals in pial veins (p = 0.000), pial arteries (p = 0.041), penetrating arteries (p = 0.001) as well as ascending veins (p = 0.002) Vascular pulsation was also reduced in Tg-SwDI when compared to wild type BCAS mice in pial veins (p = 0.000), penetrating arteries (p = 0.000), ascending veins (p = 0.000) but not in pial arteries (p > 0.05). Finally, vascular pulsation was decreased in wild type BCAS animals when compared to shams (p = 0.008). Data are presented as mean ± SEM, n = 6–7 per group. # indicates significant difference between sham and BCAS; * indicates significant difference between WT and Tg-SwDI. *p < 0.05, **, ##p < 0.01; ***p < 0.001.