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. 2022 Jan 27;22:34. doi: 10.1186/s12871-022-01574-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Midazolam altered CSF metabolome in SAH patients. A Overview of CSF metabolome in midazolam and control groups: 2-dimension score plot. 0, control; 1; midazolam; Component 1 and 2, dimensions of the PLS-DA model. Pathway analysis (B) and metabolite set enrichment analysis (C) presented the most influenced metabolic pathway by midazolam. Significantly altered metabolites were listed in (D), left column: control; right column: midazolam; red arrow: trend; *: statistical significance. E CSF biomarker of midazolam sedation, with ROC curve and cut-off value