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. 2022 Jan 26;22:40. doi: 10.1186/s12935-022-02451-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — HOOK3-FGFR1 fusion gene involved in the activation of NF-kappaB signaling pathway. a Comparative analysis of the HOOK3-FGFR1 positive patient (Case 1) and healthy donors (n = 8). The texts in the scatterplot correspond to the top 10 up-regulated and down-regulated genes (fold change > 2 and p < 0.01). b Bar plot of the differentially expressed genes from the comparison of the HOOK3-FGFR1 positive patient and healthy donors (FC > 2 and Q < 0.05) enriched in MSigDB. c Representative GSEA plots of one HOOK3-FGFR1 positive patient compared with the 19 HOOK3-FGFR1 negative MDS patients. The normalized enrichment score (NES) and nominal p-values are shown in the graph. d RayBiotech NF-kappaB Pathway Phosphorylation Array including 11 proteins was used to analyze the phosphorylation status of the signaling proteins of 293 T cells transfected with LVX-IRES-puro expression plasmids of vehicle (vector) and FLAG-HOOK3-FGFR1, respectively. Visualization and quantification of the results were performed using a Typhoon 7000 phosphorimager (GE Healthcare) and NIH ImageJ software. Left panels: images of the original blots; right panel: quantitative results. The fold change in the phosphoproteins of FLAG-HOOK3-FGFR1 was calculated relative to the vector