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. 2022 Jan 27;22:39. doi: 10.1186/s12883-022-02558-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Serum NFL highly discriminates PD from ET and controls. Serum NFL concentration in healthy controls, patients with PD and patients with ET and diagnostic accuracy. (A) Mean serum NFL level was significantly elevated in PD compared to ET and nonneurologic healthy controls. Mean levels were shown with SD; *p < 0.01. (B, C), Receiver operating characteristic curve analyses for differentiating between (B) patients with PD and age-matched healthy controls and (C) patients with PD and those with ET. AUC = area under the curve; ET = Essential tremor; NFL = neurofilament light chain; PD = Parkinson disease