TABLE 2.
Relationships between H. pylori eradication failure and variables related to the host and the strains, in NUD patients (n = 156)a
Variable | Total sample
|
Eradication failure
|
OR for failure | 95% CI | Pb | ||
---|---|---|---|---|---|---|---|
No. | % | No. | % | ||||
Treatment | |||||||
o.d. | 80 | 51.3 | 32 | 40.0 | 1.00 | ||
b.i.d. | 76 | 48.7 | 15 | 19.7 | 0.37 | 0.18–0.76 | 0.007 |
BMI | |||||||
Normal | 109 | 69.9 | 36 | 33.0 | 1.00 | ||
Inferior to normal | 20 | 12.8 | 6 | 30.0 | 0.87 | 0.31–2.45 | 0.791 |
Superior to normal | 27 | 17.3 | 5 | 18.5 | 0.46 | 0.16–1.32 | 0.148 |
Susceptibility to clarithromycin | |||||||
Susceptible | 140 | 89.7 | 31 | 22.1 | 1.00 | ||
Resistant | 16 | 10.3 | 16 | 100.0 | NAd | NAd | NAd |
cagA status of strain | |||||||
cagA+ | 84 | 53.8 | 20 | 23.8 | 1.00 | ||
cagA-lacking | 72 | 46.2 | 27 | 37.5 | 1.92 | 0.96–3.40 | 0.065 |
Ethnic origin of patient | |||||||
Caucasian | 134 | 86.5 | 38 | 28.4 | 1.00 | ||
Others | 21 | 13.5 | 9 | 42.9 | 1.89 | 0.66–5.38 | 0.18 |
Smoking status | |||||||
Nonsmoker | 119 | 76.3 | 30 | 25.2 | 1.00 | ||
Smoker | 37 | 23.9 | 17 | 45.9 | 2.52 | 1.16–5.45 | 0.018 |
Age (continuous variable)c | 0.98 | 0.95–1.0 | 0.069 |
Results of univariate analysis.
P not significant if >0.25 in univariate analysis.
Mean for total sample, 51.7 years; mean for eradication, failure, 48.5 years.
NA, not applicable.