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. 2022 Jan 13;11:802177. doi: 10.3389/fonc.2021.802177

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Copyright © 2022 Hajjaji, Aboulouard, Cardon, Bertin, Robin, Fournier and Salzet

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clonal proteome analysis in breast cancer. (A) Workflow for on tissue analysis of tumor proteomic heterogeneity using spatially resolved microproteomics guided by MALDI MSI (B) The presence of tumor proteomic clones revealed by MSI was illustrated in a primary tumor (left) from a surgical resection (case 42) and a metastatic sample (right) collected with a fine needle biopsy (case 22). In each sample vignette, the MALDI MS imaging is displayed with the histological HPS picture (upper left), the principal component analysis of the proteomic clones (upper right), the segmentation tree (middle right), and the spectra of the clones (bottom right).